NCompass Blog

When I wandered into the bookstore, I really didn’t know anything about John Green or anything he had written; after all, his target audience as a novelist has been geared toward young adults (think The Fault in Our Stars), and I am certainly not one of those. But this book is not a novel. It is a work of nonfiction, and I’ve always been fascinated by epidemiology and how it affects human history.

Author John Green learned about the western African struggle with tuberculosis when he spent time in Sierra Leone as a volunteer with Partners in Health, an international nonprofit public health organization. We are introduced to young Henry Reider; he has tuberculosis, and he is severely ill. Green met him as a patient in 2019 at Lakka Government Hospital in the west African country, and his story forms the book’s human core. Appearing much younger due to his emaciated frame, the 17-year-old Henry greets Green with infectious energy, a big goofy smile, and enthusiasm despite years of undiagnosed or mismanaged symptoms starting in childhood. Fatigue, weight loss, and night sweats had led to misdiagnoses and delayed treatment. Unfortunately, his is not a rare story. His condition had deteriorated over time into drug-resistant TB, worsened by treatment interruptions, poverty, malnutrition, and limited access to effective drugs in an under-resourced setting.

The book tracks Henry’s severe decline as doctors sought to secure harder-to-obtain medications. Through advocacy and Green’s involvement, Henry ultimately survived, recovered, and returned home healthier, displaying resilience as TB persists due to systemic inequities in healthcare access and global priorities. Henry’s story serves to humanize the statistics of a curable yet deadly disease.

Green integrates Henry’s experiences with a vivid and enlightening examination of one of humanity’s oldest and most persistent diseases. The author frames tuberculosis not merely as a medical condition but as a historical force that has shaped societies, economies, and cultures across centuries. This perspective immediately sets the tone for a book that is as much about human resilience and vulnerability as it is about science. Green suggests that “The problem is not that people with tuberculosis are poor. The problem is that people are poor, and that poverty makes them vulnerable to tuberculosis.”

Green’s book is rich in detail, and his writing is balanced by accessible language and vivid examples that make complex concepts understandable as he traces TB’s influence from ancient civilizations to the industrial revolution. Living conditions, poverty, and social structures contributed to its spread, underscoring the interconnectedness of health and society, and reminding readers that disease is never just a biological phenomenon—it is deeply tied to human economic and societal conditions.

Green’s narrative does not shy away from contemporary challenges, as it addresses the resurgence of TB in certain regions, the rise of drug-resistant strains, and current global efforts to eradicate the disease. These discussions are sobering, emphasizing that TB is far from a relic of the past. Instead, it remains a pressing issue that demands sustained attention and innovation. As Green writes, “the cure is where the disease is not, and the disease is where the cure is not.”

Overall, Everything is Tuberculosis is an insightful and thought-provoking work that blends science, history, and culture into a cohesive narrative. It is a reminder that understanding TB is not just about curing an illness—it is about confronting the conditions that allow it to flourish.

Green, John. Everything is Tuberculosis: The History and Persistence of our Deadliest Infection. Crash Course Books. 2025.